Researchers taking bold steps toward engineering new lungs

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1. Oxidative stress is an aggravating factor in Lafora rare disease Neurodegenerative Lafora disease usually becomes apparent through seizures during adolescence and puberty and occurs as a consequence of defects in glycogen metabolism and in the cellular mechanisms that are responsible for its disposal. Researchers at the University of Valencia have led a study in which they propose that Lafora could be aggravated by oxidative stress. These ideas have been put forward in a review article recently published in the journal Free Radical Biology and Medicine....
2. Benefits of calorie restriction on par with balancing protein and carb intake in mice Cutting calories through dietary restriction has been shown to lower cholesterol, improve insulin sensitivity, and even prolong life in mammals. Now, new research publishing on May 28th in Cell Reports shows that, at least in mice, low protein, high carbohydrate diets can provide benefits similar to those obtained with calorie restriction....
3. How Vitamin D May Affect Heart Disease, Diabetes How Vitamin D May Affect Heart Disease, DiabetesMice with immune cells unable to use vitamin D developed precursors of heart disease and type 2 diabetes. The mechanisms uncovered may lead to novel therapies....
4. Most Australian soldiers do not have mental resilience to deal with combat: study Most Australian soldiers do not have the high level of mental resilience needed to deal with combat, a survey of Army troops and supervisors finds....
5. Obesity and weight loss change splicing pattern of obesity and type 2 diabetes genes Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research from the University of Eastern Finland. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. However, weight loss, induced by either obesity surgery or a very low-calorie diet, reverses these changes. The findings, presented by Dorota Kaminska, MSc, in her doctoral dissertation, increase our understanding of splicing dysregulations in obesity and can result in a new, more targeted treatment and more accurate diagnostics of metabolic disorders....