Exercise Keeps Skin Healthy and Young

Exercise is proving to play an important role in skin health.

Besides the use of scientifically sound skin care with the Isagenix Rejuvity® Skincare System, new research is proving exercise is also a powerful adjunct to the health of your skin.

Just published in the journal Aging Cell, researchers from McMaster University in Ontario, Canada found exercise to be a potent therapy for halting skin aging (1). The mechanism behind the beneficial effects of exercise on skin health appears to a specific type of signaling protein called Interleukin 15 or IL-15 for short.

Many often neglect proper skin care, however, skin is the largest organ in the body and is the main barrier against infection and disease. During aging different portions of the skin like the dermal and epidermal layers deteriorate due to reductions in cells, lack of collagen synthesis, and altered tissue remodeling (2).

Aging skin cells have a lower energy metabolism, higher levels of oxidative stress, and incomplete DNA (3;4). For example, free radicals damage connective tissue which results in premature skin aging and can negatively alter DNA in the dermal layer (5;6). What researchers are starting to uncover are treatments that target skin metabolism and offer a promising way to maintain skin health in old age.

We already know that exercise has been known to improve energy metabolism. In fact, several proteins released from muscle have been noted to have important functions in other organs (7). Following this logic, the research team investigated whether exercise regulates skin metabolism and function (1).

Tissue samples from human subjects were collected at rest and immediately following an acute session of 30 minutes of exercise at 50 percent of their cycling power maximum. Next, 65 to 86 year old sedentary subjects underwent 12 weeks of twice-weekly aerobic exercise training. The training program started with participants maintaining 65 percent of heart rate max for 30 minutes and progressed by five percent every other week until intensity reached 75 percent of heart rate max, at which point the duration of exercise increased by five minutes every other week reaching 75 percent of heart rate max for 45 minutes at the end of the training intervention.

What the researchers found was IL-15 was significantly increased after exercise. Low amount of IL-15 are linked to accelerated degeneration of skin cells and helps drive the aging process (1). Higher amounts of IL-15, on the other hand, bolster a healthy cell metabolism and help reduce oxidative damage. Keep regular exercise in your fight to prevent skin gaining. While the Isagenix Rejuvity® Skincare System offers external support, exercise is able to work internally. When combined you truly have an effective skin care treatment!

References

1. Crane JD, MacNeil LG, Lally JS et al. ExerciseGÇÉstimulated interleukinGÇÉ15 is controlled by AMPK and regulates skin metabolism and aging. Aging cell 2015.
2. Fisher GJ, Kang S, Varani J et al. Mechanisms of photoaging and chronological skin aging. Archives of dermatology 2002;138:1462-70.
3. Isobe K, Ito S, Hosaka H et al. Nuclear-recessive mutations of factors involved in mitochondrial translation are responsible for age-related respiration deficiency of human skin fibroblasts. Journal of Biological Chemistry 1998;273:4601-6.
4. Lu CY, Lee HC, Fahn HJ, Wei YH. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1999;423:11-21.
5. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) 2012;4:3.
6. Schroeder P, Gremmel T, Berneburg M, Krutmann J. Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin. Journal of Investigative Dermatology 2008;128:2297-303.
7. Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology 2012;8:457-65.

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