NIH study demonstrates long-term benefits of weight-loss surgery in young people

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Thursday, October 31, 2024

Adolescents see a greater remission of type 2 diabetes compared to adults.

What

Young people with severe obesity who underwent weight-loss surgery at age 19 or younger continued to see sustained weight loss and resolution of common obesity-related comorbidities 10 years later, according to results from a large clinical study funded by the National Institutes of Health (NIH).

Study participants with an average age of 17 underwent gastric bypass or sleeve gastrectomy weight-loss surgery. After 10 years, participants sustained an average of 20% reduction in body mass index (BMI), 55% reduction of type 2 diabetes, 57% reduction of hypertension, and 54% reduction of abnormal cholesterol. Both gastric bypass and sleeve gastrectomy had similar results.

The 55% reduction in type 2 diabetes was much higher than the rates observed in adults after weight-loss surgery (18% at seven years and 12.7% at 12 years) in a recently published NIH-funded study.

Type 2 diabetes tends to progress more rapidly when it occurs in young people, and these findings demonstrate the greater health benefits and durability of bariatric surgery in youth than would be expected in similarly treated adults.

The study, known as Teen Longitudinal Assessment of Bariatric Surgery (Teen LABS), was supported by NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) through grants DK072493, DK072493, DK095710 and NIH’s National Center for Research Resources and the National Center for Advancing Translational Sciences Clinical and Translational Science Awards Program grants TR000077 and TR000114.

Data related to these findings are available for request at the NIDDK Central Repository.

Who

Voula Osganian, M.D., a pediatric clinical obesity program director at NIDDK is available to comment on this research.

Reference

Ryder, Justin et al., Ten-year Outcomes Following Adolescent Bariatric Surgery, [2024] New England Journal of Medicine. DOI: 10.1056/NEJMc2404054

The NIDDK, part of the NIH, conducts and supports research on diabetes and other endocrine and metabolic diseases; digestive diseases, nutrition and obesity; and kidney, urologic and hematologic diseases. Spanning the full spectrum of medicine and afflicting people of all ages and ethnic groups, these diseases encompass some of the most common, severe and disabling conditions affecting Americans. For more information about the NIDDK and its programs, see https://www.niddk.nih.gov.

About the National Institutes of Health (NIH):
NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.