Premenopausal Women with Low Bone Density

Premenopausal Women with Low Bone Density

Our expert is Elizabeth Shane, Professor of Medicine and Vice Chair of Medicine for Clinical and Epidemiological Research at Columbia University’s College of Physicians and Surgeons. Her research interests include premenopausal osteoporosis, bone disease associated with HIV/AIDS, bone loss due to medications and gastrointestinal diseases, and the use of high-resolution imaging to investigate the effects of various drugs and diseases on bone quality and strength.

You can hear Dr. Shane at the upcoming conference, Women’s Health 2015:  The 23rd Annual Congress, April 16-19, 2015 in Washington, DC.

Very best,

Mitzi Perdue

mperdue@liebert.com

LOW BONE DENSITY CAN OCCUR IN PREMENOPAUSAL WOMEN

Although osteoporosis is mostly a disease of older women, under certain circumstances, premenopausal women may also be vulnerable. There are disease states and medications that cause low bone density in premenopausal women including: celiac disease, cystic fibrosis, rheumatoid arthritis, epilepsy, eating disorders, and any disease with increased inflammation.   In addition to diseases and medications that can cause low bone density, certain lifestyle habits such as smoking, excessive drinking, inadequate calcium and vitamin D, and insufficient exercise, may contribute to or exacerbate premenopausal bone loss.  Some cases are genetic. In others, the cells that form new bones do not function well. Fractures can also affect women in the third trimester of pregnancy or during breastfeeding.  In other cases, we just don’t know the cause.

TESTING FOR LOW BONE DENSITY IN PREMENOPAUSAL WOMEN

In most cases, we discourage premenopausal women from having bone density exams. For one thing, it’s difficult to interpret the results in a younger woman. Even though she may be at the lower end of the bell-shaped curve for bone density, that doesn’t necessarily mean a woman is at short-term risk for fractures.  Further, a thin, petite woman may have a falsely low reading because the scan is two-dimensional, capturing height and width, but not the depth of a bone.  Also, small women don’t need large bones because their bones are not bearing a lot of weight. On the other hand, there are situations in which measuring bone density is highly appropriate.  If a premenopausal woman has any of the diseases that are known to have a bad effect on the skeleton, or if she has had a fracture that’s not easily explained by the degree of trauma (a low-trauma fracture), then a bone density scan should be performed.  A low-trauma fracture is defined as one that occurs with trauma equivalent to a fall from standing height or less, for example, a woman who breaks a bone after a fall on a sidewalk. This is in contrast to a high-trauma fracture that comes from falling down a flight of stairs or a motor vehicle accident.

WHEN A MEDICAL EVALUATION IS NEEDED

In cases where there is an unexplained broken bone, and low bone density is found on a bone density scan, it is very important do a thorough medical evaluation to make sure that there isn’t a treatable underlying cause.   Celiac disease, for example, can be asymptomatic and may only present with fractures. Diagnosing an unsuspected underlying disease, such as asymptomatic celiac disease, and treating it specifically is much more effective than treating the low bone density itself. If a woman has celiac disease, it is usually much more effective to put her on a gluten-free diet than to give her medications to increase bone density.

LIFESTYLE APPROACHES TO TREATING LOW BONE DENSITY

If an individual has low bone density but no fractures, I usually recommend some lifestyle changes along with observation rather than medications. Lifestyle changes that may help prevent fractures and improve bone density include: quitting smoking, reducing or eliminating alcohol use, and engaging in plenty of weight-bearing exercise,  such as walking, jogging, running, dancing, or using an elliptical machine. Interestingly, lifting weights doesn’t have a large effect on bone density, even though it’s a good thing to do for other reasons.

The individual should make sure she’s getting adequate calcium and vitamin D, preferably from her diet. WebMD has useful information on sources of dietary Vitamin D and calcium, http://www.webmd.com/food-recipes/guide/calcium-vitamin-d-foods. However, too much calcium could be harmful, so she should make sure that the total between diet and supplements is not much more than 1000 mg per day. Similarly, too much Vitamin D can also be harmful.   I usually recommend 1000 IU daily and then adjust to maintain the blood level at around 30 ng/ml.

BE CAUTIOUS ABOUT PRESCRIBING MEDICATIONS FOR LOW BONE DENSITY 

Prescribing medications for women of childbearing age who have low bone density is complicated because some medications can cross the placenta.  Biophosphonates are a Category C drug, meaning they should be avoided in pregnancy. Teriparatide and denosumab should not be used during pregnancy. To further complicate the issue, bisphosphonates may persist in the bones long after the patient is no longer taking them, and can still cross the placenta even after they are discontinued.  A woman of childbearing age should agree to use contraception if it is medically necessary to treat her low bone density pharmacologically.

SOURCE: Academy of Women’s Health – Read entire story here.